24.03.2000 

Part 1

CASE FOR DISCUSSION: 587.209-00d

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Clinical:                     78-y-o male, single reddish scaly lesion from buttock; 3cm in diameter.  
Clinical diagnosis: Bowen's disease
Histopathology:     Verrucous epidermal hyperplasia. Intraepidermally many Langerhans cells and
                                    large T-Lymphocytes of CD4 and CD8 subtype. Many CD30 (BerH2)-positive cells
                                    in epidermis and papillary dermis.
                                    There was no monoclonal rearrangement of the T-cell receptor gamma gene.

                                    Is this a solitary lesion:
                                    of Mycosis fungoides? / of Langerhans cell histiocytosis?

                                    or is it simply a very unusual case of lichen planus like keratosis?

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