Histology NXG (Fachübergreifende Gemeinschaftspraxis, Friedrichshafen)

Elderly patient with histological lesions similar to "necrobiosis lipoidica".
For the diagnosis look at bottom of the last picture.

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Histopathology

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Histological clue for NXG: this looks like a "caricature of necrobiosis lipoidica": there is more of everything: more necrosis, more cholesterol clefts, and much more foam cells.

NXG: look for FOAM cells + CHOLESTEROL clefts (even in very superficial biopsies which at first glance may not be representative for "classical" NXG).

	fig. 1 Superficial biopsy of NXG: Foam cells + cholesterol clefts
	fig. 2 Foam cells + cholesterol clefts
	fig. 3
	fig. 4 Excessive degeneration of collagen
	fig. 5 Abundant foam cells
	fig. 6
	fig. 7 Clue for NXG: Cholesterol clefts + foam cells
	fig. 8

Diagnosis:
NECROBIOTIC XANTHOGRANULOMA WITH PARAPROTEINEMIA

Dermatohistopathologische Gemeinschaftspraxis
Siemensstraße 6/1
88048 Friedrichshafen
Germany
Tel. : ++49/7541 / 6044- 0
Fax : ++49/7541 / 6044-10

© 1998-2010     Dermatopathologie Friedrichshafen, Bodensee, Siemensstraße 6/1, 88048 Friedrichshafen, Germany,
                         Tel. 07541/6044-0, Fax 07541/6044-10, email: dermpath@dermpath.de

                         webmistress j.schroeder@dermpath.de             letzte Aktualisierung 18.01.2008 18:30

Elderly patient with histological lesions similar to "necrobiosis lipoidica".
For the diagnosis look at bottom of the last picture.

^{Clinical
pictures click here}

fig. 1 Superficial biopsy of NXG: Foam cells + cholesterol clefts

fig. 2 Foam cells + cholesterol clefts

fig. 3

fig. 4 Excessive degeneration of collagen

fig. 5 Abundant foam cells

fig. 6

fig. 7 Clue for NXG: Cholesterol clefts + foam cells

fig. 8

Diagnosis:
NECROBIOTIC XANTHOGRANULOMA WITH PARAPROTEINEMIA

Dermatohistopathologische Gemeinschaftspraxis
Siemensstraße 6/1
88048 Friedrichshafen
Germany
Tel. : ++49/7541 / 6044- 0
Fax : ++49/7541 / 6044-10

e-mail: dermpath@dermpath.de

zum Anfang der Seite

Elderly patient with histological lesions similar to "necrobiosis lipoidica". For the diagnosis look at bottom of the last picture.

Clinical pictures click here

fig. 1 Superficial biopsy of NXG: Foam cells + cholesterol clefts

fig. 2 Foam cells + cholesterol clefts

fig. 3

fig. 4 Excessive degeneration of collagen

fig. 5 Abundant foam cells

fig. 6

fig. 7 Clue for NXG: Cholesterol clefts + foam cells

fig. 8

Diagnosis: NECROBIOTIC XANTHOGRANULOMA WITH PARAPROTEINEMIA

Dermatohistopathologische Gemeinschaftspraxis Siemensstraße 6/1 88048 Friedrichshafen Germany Tel. : ++49/7541 / 6044- 0 Fax : ++49/7541 / 6044-10

e-mail: dermpath@dermpath.de

zum Anfang der Seite

© 1998-2010 Dermatopathologie Friedrichshafen, Bodensee, Siemensstraße 6/1, 88048 Friedrichshafen, Germany, Tel. 07541/6044-0, Fax 07541/6044-10, email: dermpath@dermpath.de webmistress j.schroeder@dermpath.de letzte Aktualisierung 18.01.2008 18:30

Elderly patient with histological lesions similar to "necrobiosis lipoidica".
For the diagnosis look at bottom of the last picture.

^{Clinical
pictures click here}

Diagnosis:
NECROBIOTIC XANTHOGRANULOMA WITH PARAPROTEINEMIA

Dermatohistopathologische Gemeinschaftspraxis
Siemensstraße 6/1
88048 Friedrichshafen
Germany
Tel. : ++49/7541 / 6044- 0
Fax : ++49/7541 / 6044-10

© 1998-2010 Dermatopathologie Friedrichshafen, Bodensee, Siemensstraße 6/1, 88048 Friedrichshafen, Germany,
Tel. 07541/6044-0, Fax 07541/6044-10, email: dermpath@dermpath.de

webmistress j.schroeder@dermpath.de letzte Aktualisierung 18.01.2008 18:30